Are you having trouble with it? I didn't really have to do anything special, but I can try find out for you?
I originally only got the wacom to animate a short film in Flash and then decided to start drawing in gimp to practice digital art. I do use a pretty big monitor now though - I think it's either a 27" or 28.5". Some of my earlier stuff was just done on a laptop with the wacom or on a touch screen tab in photoshop touch! You can really see a difference between my newer stuff but I think some of that is to do with practice too.
Can't wait to upgrade to a cintiq! This old bamboo has served me well though!