Yes, a few weeks ago for the first time in 10 years, I stopped taking it and after 6 days, I started feeling much better. But I take it for urinary problems so I was forced to start taking it again. As soon as I did, the severe fatigue problems came back. So I did some research on alpha blockers which said one way they work is by lessening the affect of two hormones produced by the adrenal glands. Those hormones in turn affect the entire endocrine system as well as other systems. Which explains why I've developed symptoms of hypothyroidism, Addison's and other random illnesses. I went to see with the urologist who prescribed the alpha blocker and my primary care who both said its possible the medication is the cause. So I'm switching to Avodart but it may take six months or more before it helps so I'm stuck on the alpha blocker until then. I just don't understand why none of the doctors, between 10 to 15, never suspected the CFS could be medication induced? Very frustrating!