A nuzlocke is a challenge you can do to make the games more challenging. There are 2 core rules: 1) Catch the first Pokemon you encounter on each route and 2) If the Pokemon faints it is dead. You can add your own rules to it, but you need to have those two for it to count as a nuzlocke.
The comics and stories are basically let's plays of who their game went.
O see.. thank you for answering my question ^ ^
No problem. 
indeed keep up the great comic ^ ^