DCPanda's avatar
 Sweetie Belle being a performer seems likely, of course. Perhaps Apple Bloom might become a botanist or apothecary (owing to Twilight and Zecora's influence), emphasizing the Bloom rather than the Apple. 

Scootaloo, however...

Lauren Faust is on record as saying that she planned to have Scoots never actually fly. And that's OK. It's an important lesson for kids, knowing that maybe your path in life isn't what others or even you expected it to be. And maybe teaching that lesson, helping other ponies realize that is what she ends up doing. It's pretty much in line with what the CMC are doing now in canon, as it is.

I honestly expected Scoots' cutie mark to BE the Crusaders' Symbol when she realizes it. And then the Crusaders become this Equestria-wide organization very similar to the Girl Scouts, with Scoots as Juliette Gordon Lowe (yes I know my GS history...the wife is a lifelong GS) with Sweetie Belle and Apple Bloom helping out.